Parathyroidectomy and Cardiometabolic Risks in Patients With Primary Hyperparathyroidism.

ABSTRACT:

Importance

Primary hyperparathyroidism (pHPT) is a common endocrine disorder linked to elevated parathyroid hormone and calcium levels, which may contribute to increased cardiometabolic risk.

Objective

To evaluate the long-term cardiometabolic risks associated with pHPT and to assess whether parathyroidectomy is associated with reduced incidence of these outcomes.

Design, setting, and participants

This retrospective cohort study used data from Clalit Health Services, Israel's largest health care organization. A total of 50 199 patients diagnosed with pHPT between January 1, 2000, and November 29, 2023, and 150 265 matched controls (matched 1:3 by age, sex, and socioeconomic status) were included. Patients with secondary hyperparathyroidism were excluded. Among patient

SUBMITTER: Tsur N 

PROVIDER: S-EPMC12639482 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature