Prospective Whole-Genome Sequencing to Identify Bacterial Transmission and Its Modifiers in Neonates.

ABSTRACT:

Importance

Infants in neonatal intensive care units (NICUs) are at risk of acquiring organisms with multidrug resistance or high epidemic potential (MDRO+), which may precede invasive infections. High-resolution analysis of transmission cultures of MDRO+ may help mitigate these risks through targeted infection prevention measures.

Objectives

To assess the potential of whole-genome sequencing in resolving suspected transmission chains of MDRO+ and to identify associated risk factors for cluster involvement.

Design, setting, and participants

This prospective monocentric cohort study was conducted at a level III NICU at the Medical Center-University of Freiburg, Freiburg, Germany. Of 551 admitted infants, 434 were included because they remained on the ward for 48 hours o

SUBMITTER: Nguyen T 

PROVIDER: S-EPMC12639485 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature