Integrated biofabrication of artificial esophageal scaffolds using electrospinning, embedded DLP, and extrusion techniques.

ABSTRACT: Esophageal reconstruction faces critical challenges due to limitations in current techniques, including inadequate mechanical properties, poor tissue integration, and insufficient functional regeneration. This study presents a novel biofabrication strategy for developing artificial esophageal scaffolds by integrating electrospinning, embedded digital light processing (DLP), and extrusion-based bioprinting techniques. These scaffolds are composed of flexible electrospun polyurethane (PU) nanofibers wherein silk fibroin methacryloyl (Sil-MA) is embedded within the PU layer to enhance mechanical strength and hydrophilicity. Decellularized esophageal extracellular matrix (EdECM) is deposited onto the scaffolds to promote tissue regeneration. Comprehensive in vitro and in vivo evaluations revea

SUBMITTER: Ranganathan P 

PROVIDER: S-EPMC12639500 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature