<i>APOE ε4</i> and ischemic heart disease in American Indian/Indigenous tribal Elders.

ABSTRACT:

Objective

American Indian/Indigenous (AI) populations have the highest rate of ischemic heart disease (IHD) of any racial or ethnic group in the United States. While modifiable cardiovascular risk factors represent a well-established source of elevated IHD in AI, little is known regarding genetic IHD influences, in particular APOE ε4, which has an ancestry-dependent prevalence and effect on human disease. We sought to quantify the prevalence and association between APOE ε4 and IHD in AI communities.

Methods

We performed a cross-sectional, community-based study including tribal Elders (ages >54 years) at the Bois Forte Band of Chippewa in the state of Minnesota. We collected data pertaining to demographics, cardiovascular risk factors, APOE ε4 genotype, a

SUBMITTER: Labounek R 

PROVIDER: S-EPMC12639555 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature