Engineered calcium carbonate-modiated SAzymes with Mn-based single-atom sites for ultrasound-enhanced nanocatalytic therapy.

ABSTRACT: The construction of highly effective therapeutic nano-systems will be of great interest in the investigation of cancer treatment; however, developing such the platforms face significant challenges originated from the strict tumor microenvironment (TME). In this study, the engineered carbonate-mediated SAzyme based on UiO-66-NH₂ with Mn-based single-atom sites and calcium carbonate (CaCO₃@Mn-UiO-66-NH₂, CUM) is successfully developed for dual imaging-guided ultrasound-enhanced nano-catalytic therapy. The designed SAzyme with uniform structure and morphology exhibit good stability and suitable particles sizes. The Mn based single-atoms coordinated in the CUM show excellent peroxidase (POD)-like activity to generate high toxic hydroxyl radical (∙OH) in the TME

SUBMITTER: Wang X 

PROVIDER: S-EPMC12639588 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature