Zn²⁺ supplementation-mediated <i>IZH4</i> enhances acid tolerance in <i>Saccharomyces cerevisiae</i> via membrane lipid remodeling: A multi-omics study.

ABSTRACT: Zinc is an essential micronutrient that serves as a vital cofactor in multiple metabolic pathways, including the mechanism mediated by IZH (Implicated in Zinc Homeostasis) genes and lipid biosynthesis. Previous studies revealed that Saccharomyces cerevisiae ET008-c54 (WT) exhibited excellent fermentation performance at low pH for acidic fruit wines, with IZH4 identified as a key gene. This study investigated the specific role of IZH4 mediated under Zn²⁺ supplementation in low-pH tolerance, using greengage plum wine as a model. Based on fermentation time and sensory evaluation, the optimal Zn²⁺ supplementation level was preliminarily determined to be 2 mg/L. Further metabolomics and flavoromics confirmed that Zn²⁺ supplementation

SUBMITTER: Tian T 

PROVIDER: S-EPMC12639619 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature