Multidimensional biomimetic strategy integrating structural, functional and biological cues for enhanced tendon-to-bone interface regeneration.

ABSTRACT: Failed tendon-bone interface (TBI) healing post-reconstruction is primarily attributed to persistent pathological microenvironments and insufficient fibrocartilage differentiation. However, effective tissue engineering strategies that concurrently regulate pathological microenvironments and promote fibrocartilage regeneration remain lacking. To address this, we developed a biomimetic strategy integrating fibrocartilage stem cells (FCSCs) with a novel dual-crosslinked BGBT hydrogel. This hydrogel, composed of bacterial cellulose, gelatin methacryloyl, borax, and tannic acid, mimics the native fibrocartilage extracellular matrix architecture, provides mechanical support, and regulates the microenvironment to promote fibrocartilage regeneration. In vitro, BGBT hydrogel significantly en

SUBMITTER: Liang Z 

PROVIDER: S-EPMC12639628 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature