Photothermal-triggered non-apoptotic regulated cell death-related pathway regulation boosts systemic antitumor immunity.

ABSTRACT: Overcoming tumor cell resistance to apoptosis and immunosuppression remains a formidable challenge in tumor immunotherapy. There is a critical need to explore alternative cell death pathways to remodel the immunosuppressive tumor microenvironment (ITME), ultimately improving therapeutic efficacy. Emerging non-apoptotic regulated cell death (RCD) modalities, including ferroptosis, pyroptosis, and immunogenic cell death (ICD), have been recognized as promising strategies for tumor immunotherapy. Mild photothermal therapy (mPTT) can reshape the ITME to trigger antitumor immunity, but its clinical use is blocked by tumor cell thermotolerance. To address this, we developed a synergistic immuno-photothermal therapy within the framework of non-apoptotic RCD, aiming to modulate the ITME. It shows

SUBMITTER: Liang Y 

PROVIDER: S-EPMC12639629 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature