Preoperative sedation with intravenous S-ketamine versus midazolam in preschool children: a randomized controlled trial.

ABSTRACT:

Background

Effective management of preoperative anxiety is paramount in pediatric anesthesia, as untreated preoperative anxiety often leads to adverse clinical outcomes-most notably difficult parent-child separation and challenges during anesthesia induction. Therefore, preoperative sedation is essential for alleviating preoperative anxiety in preschool-aged children.

Methods

In this prospective randomized controlled clinical trial, children aged 2-6 years were assigned to one of two study groups: Group S (S-ketamine, 0.5 mg/kg) and Group M (midazolam, 0.08 mg/kg). The drugs were intravenously administrated in a 1:1 ratio in the anesthesia holding area. The primary outcome was the sedative effect, evaluated via the Modified Yale Preoperative Anxiety Scale (mYPAS). Second out

SUBMITTER: Liao YQ 

PROVIDER: S-EPMC12639671 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature