Genome-wide association study of Asian women identifies putative mammographic density-associated loci.

ABSTRACT:

Background

Mammographic density (MD) is a strong, heritable risk factor for breast cancer. To date, 55 independent MD-associated genetic loci have been identified through genome-wide association studies (GWASs) in women of European ancestry; however, no studies have been reported in Asian women.

Methods

To identify novel loci, we conducted genome-wide association studies (GWASs) of absolute dense, absolute nondense, and percentage area and volumetric densities, adjusting for age, body mass index (BMI), and ancestry-informative principal components, in a multi-ethnic cohort of 2,951 Asian women attending opportunistic mammography screening. We selected 175 novel loci that were associated with at least one MD phenotype at P < 5 × 10^- 6 for (a) replication in an inde

SUBMITTER: Mariapun S 

PROVIDER: S-EPMC12639730 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature