Global trends (1990-2021) and trojections to 2050 in alcohol-attributable epilepsy burden among adults over 40 years old.

ABSTRACT:

Background

Epilepsy in Middle-aged and older adults has become a growing global health burden, with long-term alcohol consumption emerging as one of the key modifiable risk factors.

Methods

Leveraging comprehensive data from the Global Burden of Disease (GBD) 2021 study, we systematically evaluated mortality and morbidity metrics - including deaths, disability-adjusted life years (DALYs), years lived with disability (YLDs), years of life lost (YLLs), and corresponding age-standardized rates (ASRs) - across 204 countries and territories. Temporal trends from 1990 to 2021 were quantified using estimated annual percentage changes (EAPCs). For burden projections through 2050, we employed three complementary modeling approaches: Bayesian age-period-cohort (BAPC) analysis, autoreg

SUBMITTER: Wang D 

PROVIDER: S-EPMC12639734 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature