Nonlinear relationship between age and the risk of hepatocellular carcinoma in patients with hepatitis B virus-related cirrhosis.

ABSTRACT:

Background

Discrepancies and uncertainties persist across various guidelines regarding specific age categories and their association with the risk of hepatocellular carcinoma (HCC). Simultaneously, a more nuanced examination is warranted to ascertain whether the association between age and HCC risk adheres strictly to a linear pattern.

Aims

To elucidate the relationship between age and risk of HCC in individuals with hepatitis B virus (HBV)-related cirrhosis.

Methods

A retrospective study conducted across two medical centers enrolled individuals with HBV-related cirrhosis, treating baseline age as a categorical variable to assess the risk of developing HCC. Restricted cubic spline regression was employed to scrutinize potential non-linear associations between age and

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12639736 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature