Rethinking a hybrid malaria chemoprevention delivery strategy for children in sub-perennial settings: a modelling study integrating age- and seasonally-targeted delivery.

ABSTRACT:

Background

The World Health Organization recommends perennial malaria chemoprevention (PMC), generally using sulfadoxine-pyrimethamine (SP) to children at high risk of severe Plasmodium falciparum malaria. Currently, PMC is given up to age two in perennial transmission settings. However, no recommendation exists for perennial settings with seasonal variation in transmission intensity, recently categorized as 'sub-perennial'. Tailored chemoprevention strategies are needed to protect children during seasons and ages of highest malaria risk. The seasonal dimension must adequately cover seasonally increased risk periods, alongside interventions that address year-round, lower intensity transmission. This study proposes a hybrid malaria chemoprevention (HMC) strategy, integrating two del

SUBMITTER: Sen S 

PROVIDER: S-EPMC12639754 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature