Comparative analysis of insulin resistance indicators in predicting reversion from prediabetes to normoglycemia.

ABSTRACT:

Background

Indicators for insulin resistance (IR) have been proposed for predicting dysglycemia; however, their comparative effectiveness in predicting reversion from prediabetes to normoglycemia remains unclear. This study aimed to compare the predictive performance of four IR indicators for normoglycemia reversion in Chinese adults with prediabetes.

Methods

This retrospective cohort study included 15,415 participants with prediabetes-fasting plasma glucose (FPG) levels of 5.6-6.9 mmol/L. Normoglycemia reversion was defined as FPG levels < 5.6 mmol/L without a diabetes diagnosis at follow-up. Baseline metabolic scores for IR (MetS-IR), triglyceride glucose (TyG) index, TyG-body mass index (TyG-BMI), and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio w

SUBMITTER: Yi J 

PROVIDER: S-EPMC12639787 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature