Deficiency of SARM1 attenuates neuronal injury and improves neurological performance in a photothrombotic stroke model.

ABSTRACT: Stroke is a major cause of morbidity and mortality worldwide. There is an urgent need for effective neuroprotective agents to reduce brain injury. SARM1 (sterile alpha and TIR motif-containing 1) has been identified as a key mediator of axonal degeneration. However, its role in stroke and the underlying mechanisms remain insufficiently understood. In the present study, a mouse model of stroke with focal infarction in the cortex was used to investigate the potential relation between SARM1 and post-stroke brain injury. We found that SARM1 expression increased in neurons of the peri-infarct cortex at an early stage after photothrombotic stroke induction (PTI) and was evenly distributed between excitatory and inhibitory neurons. Deficiency of SARM1 improved neurological performance, reduced th

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12639794 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature