SETD3 regulates Bcl-6 expression and Tfh differentiation in SLE CD4⁺ T cells by manipulating histone methylation and acetylation.

ABSTRACT:

Background

Tfh cells play a crucial role in the pathogenesis of SLE. Our previous research confirmed that SETD3, which is upregulated in CD4⁺ T cells of SLE patients, mediates the overexpression of CXCR5 by upregulating the CXCR5 promoter histones H3K4me3 and H3K36me3. However, the recent study demonstrates that SETD3, in contrast to other protein lysine methyltransferases, does not methylate histones; its sole verified substrate is H73 of actin. Consequently, the molecular mechanism by which SETD3 influences histone methylation requires further investigation. The most important transcription factor in the development and differentiation of Tfh cells is Bcl-6. Whether SETD3 can directly participate in the regulation of Tfh cell differentiation by regulating the expressio

SUBMITTER: Ding S 

PROVIDER: S-EPMC12639795 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature