Gut microbiome restoring biogenic ferritin mineral as an effective oral iron supplement for iron deficiency anemia.

ABSTRACT: Traditional iron supplements for iron deficiency anemia (IDA) have several limitations, including suboptimal absorption, gastrointestinal discomfort, and concerns regarding long-term safety. In this study, we synthesized monodisperse 6-line ferrihydrite as an innovative iron supplement, featuring a structure analogous to the natural "iron core" present in ferritin. Notably, 6-line ferrihydrite (6-Fh) was internalized by Caco-2 cells via a process independent of divalent metal transporter 1 (DMT1). Additionally, its stability as nanoparticles within the gastrointestinal tract prevents the irritation typically associated with metal ions, thereby significantly enhancing iron utilization efficiency. Consequently, compared to FeSO₄ (a traditional oral iron supplement), 6-Fh effectively stabiliz

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12639797 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature