Application of a preclinical 18-gene classifier to patients with locally advanced HNSCC.

ABSTRACT: In a previous preclinical trial on human HNSCC xenografts, 18 genes were predictive for adding cetuximab to fractionated radiotherapy. Here, we apply the corresponding 18-gene classifier to two HNSCC patient cohorts treated with combined radiochemotherapy (without cetuximab). We show that the classifier is related to EGFR expression and stratifies patients for loco-regional control (LRC) in both cohorts.

SUBMITTER: Lock S 

PROVIDER: S-EPMC12639843 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature