Investigating genetic diversity within <i>Cryptosporidium parvum</i> outbreaks using multi-locus variable number tandem repeat analysis.

ABSTRACT: Cryptosporidium parvum is a zoonotic protozoan parasite of human and veterinary public health concern that causes gastrointestinal disease. Animal contact is a major risk factor for C. parvum outbreaks which require thorough investigation through the use of molecular subtyping. Recently, a multi-locus variable-number tandem repeat analysis (MLVA) scheme was established for C. parvum, offering improved subtyping resolution compared to the commonly used single-locus 60 kDa glycoprotein gene (gp60) subtyping approach. Using the C. parvum MLVA scheme, the genetic diversity of known gp60 subtyped faecal DNA extracts collected between April 1st 2023 and March 31st 2024 was explored. A representative group of a common Scottish gp60 subtype (IIaA15G

SUBMITTER: Bacchetti R 

PROVIDER: S-EPMC12639845 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature