Nogo-B impairs efferocytosis in monocyte-derived macrophages and exacerbates septic liver injury.

ABSTRACT:

Background & aims

Efferocytosis is essential for maintaining tissue homeostasis and resolving inflammation, but this process is compromised during sepsis. This study aimed to elucidate the role of neurite outgrowth inhibitor protein B (Nogo-B) in regulating macrophage efferocytosis under septic conditions and to evaluate its potential as a therapeutic target.

Methods

We evaluated Nogo-B expression and efferocytosis in monocytes and monocyte-derived macrophages (MDMs) under septic conditions. Myeloid-specific Nogo deletion was used to assess its impact on MDM efferocytosis and septic organ injury. Mechanistic studies examined HIF-1α/ADAM17 signaling, mitochondrial calcium dynamics, metabolic activity, and endoplasmic reticulum (ER) stress. INCB081776, a dual MerTK/AXL inhibit

SUBMITTER: Zhong W 

PROVIDER: S-EPMC12639851 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature