Evaluation of submandibular gland function using quantitative ^99mTc-pertechnetate scintigraphy in submandibular gland sparing radiotherapy for head-neck cancers, a prospective longitudinal study.

ABSTRACT:

Purpose

This study evaluates the efficacy of submandibular gland sparing radiotherapy in reducing salivary dysfunction using dynamic ^99mTechnetium pertechnetate scintigraphy.

Materials and methods

Adults with head and neck squamous cell carcinoma planned for radical radiation using volumetric modulated arc radiotherapy were recruited in the study. The salivary function was assessed using ^99mTechnetium pertechnetate scintigraphy at baseline, 3-, 6-, and 12 months post-radiation. Maximum Uptake (Umax), Salivary Excretion Fraction (SEF), relative change in SEF (rSEF), and SEF ratio were calculated and compared at different time points.

Results

Between June 2022 and January 2024, 113 patients were recruited, with scintigraphy data available for 27 pa

SUBMITTER: Garg P 

PROVIDER: S-EPMC12639887 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature