Thermo-responsive shape memory biomaterials with structural and physical adaptivity for scarless personalized nerve repair.

ABSTRACT: Nerve guidance conduits (NGCs) have emerged as promising alternatives to autologous nerve grafts for peripheral nerve repair, overcoming donor site morbidity while promoting axonal regeneration. However, size and structure mismatch in conventional NGCs impairs axon sprouting, remyelination and neural regeneration efficacy. Here, we engineered a thermo-responsive self-rolling multichannel NGC comprising shape-memory poly (lactide-co-trimethylene carbonate) (PLMC), silk fibroin (SF), and reduced graphene oxide (rGO) to enable scarless regeneration with personalized anatomical matching. The electrospun PLMC/SF-rGO conduit features axially aligned inner fibers providing topographical guidance cues for directional guidance and exhibits programmable shape recovery, enabling intraoperative custom

SUBMITTER: Gao T 

PROVIDER: S-EPMC12639890 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature