Proteomics identifies complement protein signatures in patients with primary biliary cholangitis.

ABSTRACT: Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease lacking reliable biomarkers for diagnosis or prognosis. To identify plasma complement biomarkers that improve diagnosis and prognosis of PBC. We analyzed large-scale proteomic data from the UK Biobank, concentrating on complement components linked to PBC. A total of 44 PBC patients, including 13 baseline cases and 31 incident cases, were evaluated alongside matched controls based on demographic factors. Proteomic analysis revealed significantly elevated levels of complement proteins, including complement receptor 1 (CR1), complement component 1q subcomponent A chain (C1QA), complement component 1q subcomponent-like 2 (C1QL2), complement component 7 (C7), and component 9 (C9) in PBC patients (P < 0.05). Among these, C1Q

SUBMITTER: Ma X 

PROVIDER: S-EPMC12639920 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature