First-trimester pan-immune-inflammation value predicts preeclampsia in a dose-dependent linear pattern.

ABSTRACT:

Background

Preeclampsia (PE), a multisystem hypertensive disorder complicating ~ 5% of pregnancies, remains a major global cause of maternal and perinatal morbidity and mortality. First-trimester screening methods are limited in accessibility and sensitivity, underscoring the need for affordable biomarkers. The pan-immune-inflammation value (PIV), derived from routine blood counts, shows potential as a predictor, but its independent predictive utility and dose-response association with PE are not yet fully defined.

Methods

In this retrospective cohort study, the association between first-trimester PIV and subsequent development of PE was evaluated. Multivariable logistic regression was used to assess PIV as an independent predictor, adjusting for confounders including matern

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12639940 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature