Association between the systemic immune-inflammation index and mortality risk in myocardial infarction patients: a retrospective cohort study.

ABSTRACT:

Background

The systemic immune-inflammation index (SII) has shown potential as a prognostic biomarker in several diseases. This study aimed to investigate the relationship between SII and mortality in patients with myocardial infarction (MI).

Methods

A retrospective cohort study was conducted from the MIMIC-Ⅳ database (n = 774) and Harbin Medical University Cancer Hospital (n = 482). Patients were divided into four quartiles based on SII, and mortality at 28, 90, and 180 days was analyzed. Kaplan-Meier survival curves and Cox regression models adjusted for confounders were used to assess the relationship between SII and mortality. Additionally, restricted cubic splines (RCS) were used to explore the nonlinear relationship between SII and 28-day mortality.

Results

RCS

SUBMITTER: Cui B 

PROVIDER: S-EPMC12639955 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature