Spinal cord injury alters the therapeutic potential of olfactory ensheathing cells harvested in an autologous transplantation model.

ABSTRACT: Spinal cord injury (SCI) leads to irreversible loss of motor, sensory, and autonomic functions and currently has no cure. While cell therapies in animal models have shown benefits such as scar reduction and neuroprotection, their translation to humans remains limited, partly because clinical applications rely on autologous rather than healthy donor cells. This prompted us to investigate how the lesion context alters the neuro-reparative potential of olfactory ensheathing cells (OECs). OECs were cultured from healthy animals or from animals 1 week after SCI, and both populations were transplanted into recipient mice after SCI.Our results demonstrate for the first time that SCI-derived OECs display impaired therapeutic properties compared with healthy-donor OECs. Transplantation of post-inju

SUBMITTER: Delarue Q 

PROVIDER: S-EPMC12639958 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature