Immunomodulatory and regenerative effects of human umbilical cord MSC-EVs in Cutaneous Leishmaniasis.

ABSTRACT:

Background

Extracellular vesicles (EVs) derived from human umbilical cord Mesenchymal Stem Cells (hUCMSC-EVs) are emerging as promising immunomodulatory agents in inflammatory disorders. However, their potential for infectious diseases remains poorly explored.

Methods

We investigated the effects of hUCMSC-EVs in experimental Cutaneous Leishmaniasis (CL) caused by Leishmania braziliensis using both in vitro and in vivo approaches. EVs were isolated and characterized according to MISEV guidelines. Their immunomodulatory properties were evaluated in murine macrophages, and their therapeutic efficacy was tested in a preclinical model of CL.

Results

Treatment with hUCMSC-EV modulated the phenotype of L. braziliensis-infected bone marrow-derived macrophages toward a mixed M

SUBMITTER: Borba PB 

PROVIDER: S-EPMC12639967 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature