Programmed PTH pulsatility coupled with piezoelectric stimulation via ultrasound-activated scaffolds synergizes deep bone defect regeneration.

ABSTRACT: Large bone defects in deep anatomical regions continue to pose significant clinical challenges for osteogenic reconstruction. While pulsatile low-dose parathyroid hormone (PTH) administration shows therapeutic potential for bone regeneration, its effective delivery to deep tissue defects remains problematic. To address this limitation, we developed a novel piezoelectric scaffold (KM@PTH) by integrating PTH with potassium sodium niobate (KNN)-mesoporous bioactive glass (MBG) composites. The KM@PTH system achieves synergistic deep bone regeneration by coupling ultrasound-activated piezoelectric stimulation with spatiotemporally programmed PTH pulsatility, where electromechanical microcurrents and biochemical signaling collaboratively enhance osteogenesis. This dual-modality approach initiate

SUBMITTER: Wang X 

PROVIDER: S-EPMC12640049 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature