Frailty Among Patients With ADPKD.

ABSTRACT:

Introduction

Autosomal dominant polycystic kidney disease (ADPKD) is a major inherited cause of end-stage kidney disease (ESKD), associated with various systemic complications. Frailty, a degenerative condition linked to adverse health outcomes, may be influenced by ADPKD and its complications; however, data on this association is limited. This study investigated whether ADPKD is associated with increased risk of incident or worsening frailty.

Methods

We conducted a retrospective cohort study, using the National Taiwan University Hospital Integrate Medical Database (2006-2021). Adults with ADPKD or simple kidney cysts (SKCs) were identified. After applying exclusion criteria and 1:4 propensity score (PS) matching, 775 patients with ADPKD and 3100 matched SKC controls were in

SUBMITTER: Wang J 

PROVIDER: S-EPMC12640067 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature