Illuminating the FGFR fusion landscape in Chinese patients: unveiling novel molecular insights and clinical implications.

ABSTRACT:

Background

Despite the increasing approval and ongoing clinical trials of FGFR-targeted therapies, accurately detecting FGFR fusions remains a challenge due to limited research, low incidence rates, complex fusion partner distribution, and unique kinase domain distribution.

Methods

We conducted a multicenter study to comprehensively profile FGFR fusions in the largest Chinese pan-cancer cohort to date, comprising 118 FGFR fusions from 114 individuals. Both DNA- and RNA-based sequencing approaches were utilized to reveal novel and fundamental features of FGFR fusion.

Results

Our research reveals an incidence rate of 0.96% for FGFR rearrangements within this Chinese cohort, including a high incidence rate of FGFR fusions (40%) in parotid gland carcinoma. However, this i

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12640125 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature