Lipid metabolism and inflammation as key drivers in preterm birth: A comprehensive analysis.

ABSTRACT:

Objective

To investigate the alterations in lipid metabolites and circulating inflammatory factors associated with preterm birth, elucidate their interactions, and uncover the underlying pathophysiologic mechanisms. By identifying potential predictive biomarkers and informing the development of effective therapeutic interventions, this research seeks to improve maternal and neonatal health outcomes.

Methods

This study included 179 lipid species (n = 7174) and 91 circulating inflammatory factors (n = 14 824) as exposure variables, with preterm birth data from the FinnGen database (n = 186 212) serving as the outcome variable. We applied a two-sample Mendelian randomization approach and mediation analysis techniques to identify specific biomarkers causally associated with pret

SUBMITTER: Xiao S 

PROVIDER: S-EPMC12640176 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature