Evolutionary origins of spinal cord tumors: A cross-species systematic review.

ABSTRACT:

Objective

Intradural spinal cord tumors, particularly intramedullary glial neoplasms such as astrocytomas, ependymomas, and oligodendrogliomas, are rare in humans but pose significant diagnostic and therapeutic challenges. Despite their clinical importance, little is known about their evolutionary origins or cross-species presentation. This study aimed to synthesize existing veterinary literature on spontaneous intradural spinal tumors in non-human animals to uncover patterns in clinical symptoms, tumor distribution, and histopathological features that may inform human spinal oncology.

Methods

We conducted a systematic review of Medline, Embase, and Web of Science using a Preferred Reporting Items for Systematic Reviews and Meta-Analyses-guided approach. Studies were screene

SUBMITTER: Urreola G 

PROVIDER: S-EPMC12640201 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature