JAK Inhibition Prevents Bone Loss and Reduces Inflammation in Experimental Periodontitis.

ABSTRACT:

Aims

This study aimed to investigate the role of Janus kinase (JAK) signaling in the pathogenesis of periodontitis by evaluating the effects of pharmacological inhibition of JAK isoforms (JAK1 and JAK3) on periodontal inflammation and ligature-induced alveolar bone loss.

Methods

Experimental periodontitis (EP) was induced by ligature placement around the mandibular first molars of rats. Concurrently, animals (n = 10 per group) received either a JAK1-3 inhibitor (JAK1-3i group), a JAK3 inhibitor (JAK3i group), or distilled water (EP group) via daily intragastric gavage for 7 days. A control group received only distilled water without ligature placement. Following euthanasia, the mandibles were evaluated using microcomputed tomography for bone loss, stereometric analysis for i

SUBMITTER: Godoi MA 

PROVIDER: S-EPMC12640214 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature