Limosilactobacillus reuteri-Fusobacterium nucleatum Interactions Modulate Biofilm Composition and Immunogenicity.

ABSTRACT:

Aim

The interactions between Limosilactobacillus reuteri and oral bacteria are poorly understood. This study seeks to characterize how two strains of L. reuteri coaggregate with Fusobacterium nucleatum, determining the impact on the biofilm composition and immunogenicity.

Methods

A series of in vitro experiments was conducted using L. reuteri DSM 17938 and ATCC PTA 5289, Fusobacterium nucleatum ATCC 25586, and Porphyromonas gingivalis W50. The coaggregation between individual strains of L. reuteri, F. nucleatum, and P. gingivalis was evaluated using the tube coaggregation assay and confocal microscopy. Biofilm compositions were determined by confocal microscopy and culture. The effect of coaggregation on the immunogenicity of L. reuteri-F. nucleatum aggregates were evaluated

SUBMITTER: Yang L 

PROVIDER: S-EPMC12640217 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature