Causal Relationship Between Galectins With Neuroblastoma: A Mendelian Randomization Study.

ABSTRACT: Galectins are a family of proteins that are involved in various aspects of cancer, including tumor growth, cell migration, invasion, and metastasis. Galectins are subdivided into three families: prototype (such as Gal-1), chimera type (such as Gal-3), and tandem repeat type (such as Gal-9). Despite the evidence linking galectins to the risk of neuroblastoma (NB), the causal association between galectins and NB remains unclear. The primary objective of this study is to clarify the causal effect of galectins (including Gal-1, Gal-3, and Gal-9) on NB risk through a two-sample Mendelian randomization (MR) study. The MR study was performed using summary statistics from extensive genome-wide association studies. Single-nucleotide polymorphisms (SNPs) related to the exposure variables were used a

SUBMITTER: Long C 

PROVIDER: S-EPMC12640329 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature