Single-cell landscape of the tumour immune microenvironment in human gynaecologic malignancies.

ABSTRACT:

Background

The immune microenvironment of the three most common gynaecological malignancies-tubo-ovarian cancer, endometrial cancer and cervical cancer-has not been systematically studied, limiting clinical application.

Methods

This study analyses 272 389 CD45+ immune cells by integrating publicly available single-cell RNA sequencing (scRNA-seq) data from 111 tumour and non-malignant tissue samples. We identified distinct subsets within immune cells: 11 for monocytes/macrophages, six for CD4 T cells, eight for CD8 T cells and five for B cells, detailing their distribution, prevalence and distinct functions.

Results

A pro-angiogenic macrophage subset linked to NF-κB signalling was associated with worse clinical outcomes and an interferon-primed macrophage subset correl

SUBMITTER: Yin S 

PROVIDER: S-EPMC12640613 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature