Growth/Differentiation Factor 15 Promotes a Pro-Regenerative Response in Chondrocytes Upon Cartilage Injury.

ABSTRACT: Posttraumatic osteoarthritis (PTOA) is a special form of osteoarthritis (OA), developing after joint injuries. Except for some minor clinical differences, no biologic marker has yet been identified to distinguish idiopathic OA (IOA) from PTOA. In this study, we investigated the expression of the stress-responsive cytokine growth differentiation factor 15 (GDF-15) in clinical samples from the Ulm OA study cohort and in a human ex vivo cartilage trauma model. GDF-15 levels were significantly higher in synovial fluid of PTOA patients as compared to IOA patients. We confirmed that fibroblast-like synoviocytes secreted GDF-15 after stimulation with medium of ex vivo-traumatized cartilage. Moreover, GDF-15 and its receptor, GFRAL, were elevated in highly degenerated OA cartilage. By means of a h

SUBMITTER: Marques SS 

PROVIDER: S-EPMC12640616 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature