DHCR7: from sterol biosynthesis to oncogenic role in colorectal cancer.

ABSTRACT:

Objective

7-Dehydrocholesterol reductase (DHCR7) is an enzyme that plays a crucial regulatory role in sterol biosynthesis and has been implicated in tumorigenesis and progression. This study aims to elucidate the biological function of DHCR7 in the pathogenesis of colorectal cancer (CRC).

Methods

By integrating multi-omics data (including public genomic databases and mass spectrometry data from clinical samples) and establishing in vivo and in vitro experimental systems (encompassing animal models and CRC cell lines with gene overexpression and knockdown), we systematically investigated the functional role of DHCR7 in CRC. A multimodal research strategy combining bioinformatics analysis with molecular biology experiments (Quantitative Real-Time Polymerase Chain

SUBMITTER: Zhou C 

PROVIDER: S-EPMC12640638 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature