MAFF inhibits angiogenesis in non-small cell lung cancer by suppressing YAP1 nuclear translocation.

ABSTRACT:

Objective

To investigate the roles of MAFF and Yes-associated protein 1 (YAP1) in regulating angiogenesis in non-small cell lung cancer (NSCLC) and to explore the mechanism through which MAFF inhibits angiogenesis by suppressing YAP1 nuclear translocation.

Methods

Bioinformatics analysis was used to assess MAFF expression and its associated regulatory pathways. Clinical samples from NSCLC patients were analyzed by immunohistochemistry (IHC) to evaluate the correlation between MAFF expression and microvessel density (MVD). Cellular experiments were conducted to examine the effects of MAFF overexpression on proliferation, migration, and angiogenesis. Western blot (WB) and immunofluorescence (IF) analyses were performed to assess the expression of YAP1, vascular endothelial gro

SUBMITTER: Ding Y 

PROVIDER: S-EPMC12640644 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature