Optimizing Markers for Chronic Lymphocytic Leukemia Diagnosis by Flow Cytometry: Results From the Nationwide Thai Lymphoma Study Group.

ABSTRACT:

Introduction

Accurate diagnosis of chronic lymphocytic leukemia (CLL) is crucial for effective management. Although recent advancements in flow cytometry have significantly improved diagnostic accuracy, distinguishing atypical cases of CLL remains challenging. This study aimed to identify specific markers to enhance CLL diagnosis and prognostic assessment.

Methods

Blood or bone marrow from patients presenting with persistent lymphocytosis (> 5 × 10³/μL) was collected. Flow cytometric analysis was performed using a customized CLL panel to evaluate the expression of CD markers for the diagnosis of CLL. Clinical and laboratory data were reviewed to support the CLL diagnosis.

Results

A total of 228 patients were included in the study, including 206 patients (90

SUBMITTER: Sathitakorn O 

PROVIDER: S-EPMC12640788 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature