Association between volatile organic compound co-exposure and the prevalence of rheumatoid arthritis: a nationwide cross-sectional study.

ABSTRACT:

Background

Environmental contaminants, especially volatile organic compounds (VOCs) and their metabolites (mVOCs), are of significant interest for treating autoimmune diseases due to their potential immunomodulatory effects. This study aimed to assess the association between urinary mVOCs and the risk of rheumatoid arthritis (RA) in U.S. adults.

Methods

A total of 4,622 adults, including 296 participants with RA, were included in the present study utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2020. Sixteen mVOCs were selected for the analysis while controlling for potential confounders. Weighted logistic regression models were employed to assess the association between individual mVOCs and RA risk. Least absolute shrinkage and

SUBMITTER: Ren T 

PROVIDER: S-EPMC12640827 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature