A mitochondrial lipid metabolism-related gene signature predicts prognosis and immune landscape in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is a highly aggressive gastrointestinal malignancy with significant global health consequences. While mitochondrial lipid metabolism genes are known to influence CRC progression, their prognostic relevance remains inadequately explored.

Methods

This study systematically evaluated the expression profiles and prognostic significance of mitochondrial lipid metabolism-related genes in CRC patients. A risk model was constructed using data from the TCGA and GEO databases. Additionally, we examined the tumor microenvironment (TME), immune cell infiltration, tumor mutation burden, microsatellite instability (MSI), and drug sensitivity. Key genes associated with core mitochondrial lipid metabolism were identified and functionally validated through a

SUBMITTER: Wang H 

PROVIDER: S-EPMC12640859 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature