Impact of iron chelation therapy on mitochondrial function, vascular integrity and inflammation in transfusion-dependent myelodysplastic syndromes.

ABSTRACT:

Background

Patients with myelodysplastic syndromes (MDS) frequently develop chronic transfusion dependence, leading to progressive iron overload. This accumulation of non-transferrin-bound iron (NTBI) contributes to oxidative stress, mitochondrial dysfunction, endothelial damage, impaired vascular regeneration, and heightened inflammation.

Objectives

To assess whether iron chelation therapy can reverse cellular and vascular injury, redox imbalance, and immune dysfunction in transfusion-dependent MDS patients.

Methods

Peripheral blood from 23 transfusion-dependent MDS patients was analysed in a paired pre-/post-treatment design. Patients received daily oral deferasirox at standard clinical dosing for approximately 6 months (median). Flow cytometry was employed to evalu

SUBMITTER: Garcia-Delgado R 

PROVIDER: S-EPMC12640865 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature