The Role of Metabolites in CSF on NAFLD Development: A Mendelian Randomisation Analysis.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition linked to metabolic syndrome. Recent studies suggest that metabolites in cerebrospinal fluid (CSF) may play a role in NAFLD development; however, the specific causal relationship between the two remains unclear.

Methods

This bidirectional two-sample Mendelian randomisation (MR) study analysed the causal relationships between 337 CSF metabolites and NAFLD. We used genome-wide association study (GWAS) datasets from the OpenGWAS and FinnGen databases. MR analysis was mainly conducted through the inverse-variance weighted method from the 'TwoSampleMR' R package, and sensitivity analyses were conducted to validate findings.

Results

A total of 24 CSF metabolites were found to have si

SUBMITTER: Liang F 

PROVIDER: S-EPMC12640884 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature