Neutrophil-to-lymphocyte ratio predicts inpatient gout recurrence: a large-scale multicenter retrospective cohort with machine-learning validation.

ABSTRACT:

Background

The neutrophil-to-lymphocyte ratio (NLR) is an accessible marker of systemic inflammation. However, its prognostic value for inpatient gout recurrence, particularly in comparison with traditional biomarkers, remains unclear. This study aims to investigate the association of NLR with inpatient gout recurrence, and compare its performance with traditional markers.

Methods

In this international, multicenter retrospective cohort study, hospitalized patients with gout were enrolled from the GoutRe cohort (China, 2010-2025) and MIMIC-IV cohort (USA, 2008-2019). Restricted cubic spline, Cox regression and competing risk models were deployed to visualize and assess the association of NLR with inpatient gout recurrence risk. Model performance was evaluated using the C-stat

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12640940 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature