Global, regional, and national burden of infertility attributable to polycystic ovary syndrome, 1990-2021: results from the Global Burden of Disease Study 2021.

ABSTRACT:

Background

Analyzing the temporal trends, inequalities, and predictions of the infertility burden among women of childbearing age due to polycystic ovary syndrome.

Methods

We employed a connection point regression analysis to carefully examine the temporal trends of PCOS-related infertility from 1990 to 2021. An age-period-cohort model was used to assess changes in prevalence across different ages, time periods, and birth cohorts. We also used Bayesian predictive models to forecast future burdens, conducted decomposition analyses to identify key drivers, and assessed health inequalities.

Results

From 1990 to 2021, the global age-standardized prevalence rate of PCOS-related infertility increased from 475.54 to 638.15 per 100,000 population, and the years lived with dis

SUBMITTER: Liang Y 

PROVIDER: S-EPMC12640974 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature