Assessing the role of iodination degree on biodegradation kinetics and transformation pathways of iodinated contrast media and derivatives.

ABSTRACT: Triiodinated aromatic compounds used as iodinated contrast media in medical imaging are poorly biodegradable. Reductive dehalogenation enhances biotransformation, but the specific influence of iodination degree on biodegradation remains unclear. This study investigated the biodegradation of twelve model substances: iopromide and diatrizoate (both iodinated contrast media), 5-amino-2,4,6-triiodoisophthalic acid (ATIA, a precursor and transformation product), and their diiodinated, monoiodinated, and deiodinated derivatives. Biodegradation kinetics were assessed in Zahn-Wellens tests and nitrate-reducing aquifer material-water batch tests. DT₅₀ values were calculated to compare degradation rates. Transformation pathways were reconstructed based on literature data and detected tran

SUBMITTER: Bartels Y 

PROVIDER: S-EPMC12641039 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature