The precuneus and posterior cingulate gyrus support temporal orientation in Alzheimer's disease.

ABSTRACT: Although the classifications of 'past,' 'present,' and 'future' are considered abstract concepts, we naturally understand them. Those classifications were named 'A-series' time by McTaggart in 1908. Alzheimer's disease (AD) is the most common type of dementia, with initial symptoms generally including temporal disorientation. This study aims to (1) elucidate the impairment process of temporal cognition in AD by administering A-series temporal tasks to individuals with AD, mild cognitive impairment (MCI), and healthy controls, and (2) clarify the relationship between temporal cognition at each stage of impairment and cerebral blood flow (CBF). A diagnosis of AD (n = 37), MCI (n = 10), and no dementia (ND) (n = 10) took part. The 'A-series' task consisted of eleven short sentences that were

SUBMITTER: Futamura A 

PROVIDER: S-EPMC12641088 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature