Luteolin induces apoptosis in Philadelphia chromosome-positive acute lymphoblastic leukemia cell by regulating the PI3K/AKT signaling pathway.

ABSTRACT:

Introduction

Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) represents the most prevalent genetic subtype of adult acute lymphoblastic leukemia (ALL). Despite the availability of targeted therapy regimens, patients with comorbidities and older patients have poor prognoses. They are prone to relapse, necessitating the urgent identification of new safe and effective treatment options. Luteolin (LUT), a natural flavonoid compound, has demonstrated significant anticancer activity. However, its mechanism of action in the context of Ph + ALL remains poorly understood. The objective of this study was to elucidate the potential mechanisms underlying the action of luteolin in Ph + ALL.

Methods

Luteolin-related targets and Ph + ALL associated targets were col

SUBMITTER: Ren Q 

PROVIDER: S-EPMC12641114 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature