Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Turkiye: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

ABSTRACT:

Objectives

To determine the antibiotic susceptibility of Streptococcus pneumoniae and Haemophilus influenzae from community-acquired respiratory tract infections from four hospitals in Türkiye in 2018-21.

Methods

MICs were determined by CLSI methodology, and susceptibility was interpreted using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

Results

S. pneumoniae (n = 142) and H. influenzae (n = 315) isolates were collected. Penicillin susceptibility in pneumococci was 35.9% by CLSI oral/EUCAST low-dose breakpoints and 82.4% by EUCAST high-dose/CLSI intravenous administration. Similar susceptibility (78.2%-82.4%, CLSI) was observed for ceftriaxone, amoxicillin/clavulanic acid, amoxicillin and cefotaxime. Other cephalosporins, tetracyclines, macro

SUBMITTER: Torumkuney D 

PROVIDER: S-EPMC12641130 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature